Vioxx Side-effects: Possible Explanation

 Mooshee.com - The target of these drugs is an enzyme called COX-2, which is produced in response to infection or injury and releases pain- and fever-inducing byproducts. Thus blocking COX-2 reduces pain.

But blocking Cox-2 in mice, according to the new study, also stimulated the production of a protein called tissue factor, or TF, which initiates blood clotting. As heart attacks and strokes are often triggered by blood clots, it is possible that the production of TF is in part responsible for the drug's adverse side-effects in humans.

In the drug-treated mice, the high levels of TF in the blood were countered by administering TF-reducing drugs. Thus it is theoretically possible to treat people safely with Vioxx and other Cox-2 inhibitors if existing TF-blocking drugs are given simultaneously.

The new study will be published online in the The Journal of Experimental Medicine on August 27.




--------------------------------
Article based on information provided by: Journal of Clinical Investigation, Ann Arbor, Michigan U.S.A.
Adapted and published by: Mooshee.com
Originally released on: September 10



Next Article: Alcoholics Show Deficits In Their Ability To Perceive Dangerous Situations
More Articles On: Heart Conditions, Pain Control, Diseases and Conditions, Pharmacology,

 

Google